Effects of expiratory effort on lung collupse and diaphragmatic contraction during mechanical ventilation

Effects of expiratory muscle use on lung volume and diaphragmatic contraction in patients under mechanical ventilation - Effects of expiratory muscle use on respiratory mechanics

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045278

Enrollment

Registered

2021-11-01

Start date

2021-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with acute hypoxemic failure (PaO2/FIO2 ratio less than 300 mmHg) and expiratory flow limitation supposed to be on mechanical ventilator for more than 48 hours

Exclusion criteria

Exclusion criteria: Diaphragmatic dysfunction, history of neuromuscular disease, continuous infusion of neuromuscular blocker, pneumothorax/pneumomediastinum, esophageal varix, hystory of gastric or esophageal surgery, pregnancy, ready for extubation within 48 hours, disagree with th e study

Design outcomes

Primary

Measure	Time frame
Thickening fraction of expiratory muscles, expiratory gastric pressure and expiratory transpulmonary pressure	—

Countries

Japan

Contacts

Public ContactTaiga Itagaki

Tokushima University Hospital Department of emergency and disaster medicine

taiga@tokushima-u.ac.jp+81-88-633-9347

Outcome results