None listed
Conditions
Interventions
400mcg/day folic acid supplementation for 120 days
800mcg/day folic acid supplementation for 120 days
Placebo for 120 days
Sponsors
Kagawa Nutrition University
Sendai Shirayuri Women`s University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Females between the ages of 18 and 25 years old at the time of obtaining consent to participate in this study
Exclusion criteria
Exclusion criteria: 1) Suffering from or history of serious hepatic disorder, renal, cardiac, pulmonary, or gastrointestinal (including gastrectomy) disease, diabetes, food allergy, or other serious disease 2) Taking medications which are related to lipid and/or folate metabolism that may affect outcomes in this study. 3) Pregnant, lactating women, or planning to become pregnant. 4) Systolic blood pressure < 90 mmHg 5) Donated component blood or 200 mL of whole blood drawn for one month prior to the start of this study 6) 400 mL of whole blood drawn for 4 months prior to the start of this study 7) 800 mL of whole blood drawn for 12 months prior to the start of this study 8) Participating other clinical trials, or within 4 weeks of completion of the clinical trial 9) BMI of 30 or higher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-methyltetrahydrofolate | — |
Secondary
| Measure | Time frame |
|---|---|
| serine, glycine, vitamin B2, pyridoxine, pyridoxamine, methionine, homocysteine, choline, betaine, dimethylglycine, s-adenosylmethionine, s-adenosylhomocysteine, cystathionine, cysteine, taurine, unmetabolized folic acid | — |
Countries
Japan
Contacts
Public ContactKumiko Shoji
Kagawa Nutrition University Basic Nutrition Laboratory
Outcome results
None listed