All diseases for which thiopurine preparations are used
Conditions
Interventions
None listed
Sponsors
Tohoku University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients: Women over 20 years old. Any underlying disease is acceptable. Then, patients who satisfy any one of A or B. A) Female patients who became pregnant while taking a thiopurine preparation (thiopurine can be discontinued after pregnancy) B) Patients who have been treated with a thiopurine preparation for more than 60 days during pregnancy Male partner (participation required*): Male patients aged 20 years or older. Male partner with pregnancy corresponding to either A or B above Child (participation required* for children who are pregnant while taking thiopurine): Any age or sex All children of patient/partner pairs participating in this study Children who became pregnant or gave birth during the period when they were not taking thiopurine products can also participate voluntarily. However, if the child is born in a pregnancy during which the patient was taking thiopurine, the child's participation is *required* in principle.
Exclusion criteria
Exclusion criteria: Cases in which the medication status at the time of pregnancy cannot be determined. Cases in which all the specimens of the partner (required) and the child (required for children born in pregnancies while taking thiopurine, optional for other pregnancies) are not available.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of NUDT15 genotype in infants for each NUDT15 genotype pair of parents | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of pregnancy complications, frequency of genetic mutations in children, and analysis of transmission disequilibrium in pregnancies taking thiopurine | — |
Countries
Japan
Contacts
Public ContactYoichi Kakuta
Tohoku University Hospital Division of Gastroenterology
Outcome results
None listed