Frequent post-operative monitoring of colorectal cancer using individualized ctDNA validated by multi-regional molecular profiling

Frequent post-operative monitoring of colorectal cancer using individualized ctDNA validated by multi-regional molecular profiling - Circulating tumor DNA monitoring in colorectal cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045114

Enrollment

150

Registered

2021-08-15

Start date

2016-03-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Pre-operative colorectal cancer patients with clinical Stage II or higher. 1. Patients must have given written an informed consent 2. Histologically confirmed colorectal cancer

Exclusion criteria

Exclusion criteria: 1. Patients who do not wish to pursue standard of care therapy 2. patients who are considered ineligible for enrolling the study by a principal investigator or sub-investigator

Design outcomes

Primary

Measure	Time frame
ctDNA dynamics and clinical relapse by conventional surveillance modalities are compared if ctDNA provides useful information on the early detection of relapse.	—

Secondary

Measure	Time frame
1. Association of pre-treatment ctDNA detection and tumor genetic and proteomic heterogeneity 2. ctDNA monitoring and disease-free confirmation 3. Pretreatment ctDNA detection and overall survival 4. Pretreatment ctDNA detection and disease free survival 5. ctDNA dynamics and treatment efficacy 6. Specificity and sensitivity of ctDNA test for relapse	—

Countries

Japan

Contacts

Public ContactTakeshi Iwaya

Iwate Medical University Hospital Department of Surgery

tiwaya@iwate-med.ac.jp0196137111

Outcome results