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Cross-sectional study on autonomic predictive responses and interoception to elucidate the pathogenic mechanism of somatic symptom disorder

Cross-sectional study on autonomic predictive responses and interoception to elucidate the pathogenic mechanism of somatic symptom disorder - Study to elucidate the mechanism of somatic symptom disorder

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000045036
Enrollment
300
Registered
2021-08-02
Start date
2021-08-02
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Somatic symptom and related disorders

Interventions

None listed

Sponsors

Keio University School of Medicine Department of Neuropsychiatry
Lead Sponsor
Keio University Faculty of Letters
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: <Healthy group> (1) Those who are able to participate in all experiments and answer the questionnaires. (2) Those who have no history of mental illness in the past, or those who have had a history of mental illness and have recovered for at least two years. (3) Those who have physical illnesses that the principal investigator judges will not interfere with their participation in the study. (4) Those who are at least 20 years old but less than 60 years old at the time of study participation. (5) Those who can provide written consent to participate in the study. <Disease group> (1) Those who can participate in all experiments and answer the questionnaire. (2) Those who have been diagnosed as somatic symptom and related disorders (including pain disorders, psychophysiological disorders, and autonomic disorders) by medical examination. (3) Those who have no history of psychiatric disorders other than somatic symptoms and related disorders, or those whose participation in the study is judged by the principal investigator to be safe even if they do have a history of psychiatric disorders. (4) Those who have physical illnesses that the principal investigator can judge will not interfere with their participation in the research. (5) Those who are at least 20 years old and under 60 years old at the time of participation in the study. (6) Those who can provide written consent to participate in the study.

Exclusion criteria

Exclusion criteria: (1) Patients who are judged by the principal investigator to have a serious mental illness that makes it difficult for them to participate in the research. (2) Patients who are judged by the principal investigator to have a serious physical illness that makes it difficult for them to participate in the research. (3) Patients who are judged by the principal investigator to have serious physical illnesses that make it difficult for them to participate in the research.

Design outcomes

Primary

MeasureTime frame
Interrelationships among autonomic responses, interoception, and cognitive function

Secondary

MeasureTime frame
1)Autonomic responses (baroreceptor sensitivity, heart rate variability), 2) accuracy of interoception, 3) body image in the embody task, 4) meaningful decision traits (jumping to conclusion task, automatic thinking task), 5) sensory classification tasks, 6) pain threshold (using pain quantitative analyzer), 7)physical symptom assessment using variable questionnaires(PHQ-15, SSS-8, SSD-12, SSAS, SHAI, BPI, HADS, K10, PCS, MAIA, FFMQ, CFQ, AAQ2, SF-8, EQ-5D, TAS-20, AQ-J, IAS-J, IATS-J), 8) head MRI including resting state-functional MRI

Countries

Japan

Contacts

Public ContactYuki Mashima

Keio University School of Medicine Department of Neuropsychiatry

yukimashima@keio.jp03-5363-3829

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026