Arteriosclerosis
Conditions
Interventions
Sixty subjects were randomly divided into 30 test food (palatinose) intake groups using a random number table (randomized controlled trial).
Sixty subjects were randomly divided into 30 control food (
Sponsors
Center for Fundamental Education, teikyo University of Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Those who can adjust their schedule 2) Body mass index between 18.5 and less than 25 kg/m2 3) Those who can follow the precautions for participation in the experiment 4) No smoking habit in the past 5) Those who have not been diagnosed with any abnormality in blood test, urine test, chest X-ray, electrocardiogram, etc. in a medical examination within one year 6) Those who prefer jelly and consume it regularly
Exclusion criteria
Exclusion criteria: (1) Subjects with chronic diseases (cardiovascular diseases, cardiovascular complications, diabetes: fasting blood glucose level of 126 mg/dl or higher, blood glucose level of 200 mg/dl or higher at any time, 75gOGTT 2-hour blood glucose level of 200 mg/dl or higher, hypertension: 140/90 mmHg or higher, hyperlipidemia: LDL 120-139 mg/dl or higher, HDL less than 40 mg/dl, triglycerides 150 mg/dl or higher, etc.) after checking the health certificate. (2) If the subject has serious physical symptoms that make it difficult to cooperate in the study. (3) Subjects who have experienced fainting due to vasovagal reflex during injection or intravenous infusion. (4) Those who have experienced chest pain during exertion or at rest. (5) Patients with pacemakers or other implantable medical devices (5) Those who are using an implanted medical device such as a pacemaker (6) Other cases in which the investigator judges that participation in the survey is inappropriate (7) Those who are not taking any medication or supplements. (8) Those who do not exercise regularly. (9) Those who have not had a medical checkup within one year. (10) Those who cannot be confirmed to be normal after undergoing a medical examination that lacks items such as blood test, urine test, chest X-ray, and electrocardiogram in the medical examination mentioned in the participation criteria (4).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sixty subjects will be randomly divided by a random number table into two groups: 30 subjects in the test food (palatinose) intake group and 30 subjects in the control food (sucrose) intake group (randomized controlled trial). Subjects will come to the measurement room to measure their height, weight, body fat percentage, and body mass index before (before the intervention), 4, 8, and 12 weeks after (total of 4 visits) the intake of 25g of the test or control food per day, and after 9:00 pm on the night before the measurement, with no intake other than water and empty stomach on the day of the measurement (early morning fasting). Then, systemic arterial, proximal aortic, and aortic stiffness, brachial and ankle arterial blood pressure, heart rate, blood glucose level, blood insulin concentration, and endothelin-1 (vasoconstrictor) will be evaluated before and 60 and 120 minutes after oral intake of the 75g glucose tolerance test carbohydrate solution. | — |
Countries
Japan
Contacts
Public ContactRyota Kobayashi
Teikyo University of Science Center for Fundamental Education
Outcome results
None listed