Dose effects of headward fluid shift combined with hypercapnia on cerebral blood flow regulation

Dose effects of headward fluid shift combined with hypercapnia on cerebral blood flow regulation - Effects of HDT and CO2 on cerebral blood flow regulation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044981

Enrollment

Registered

2021-07-28

Start date

2021-07-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult volunteers

Interventions

10-min exposure to 3% CO2 and -5 degree head down tilt 10-min exposure to 3% CO2 and -15 degree head down tilt 10-min exposure to 3% CO2 and -30 degree head down tilt

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adult consented to participate in this study.

Exclusion criteria

Exclusion criteria: Exclusion criterion includes failure to obtain CBF velocity signals from the right MCA by TCD and having medical history regarding cardiovascular health.

Design outcomes

Primary

Measure	Time frame
Changes in middle cerebral artery blood velocity (MCAv), gain, coherence and phase between arterial blood pressure and MCAv during 10-min exposure to CO2 with head-down tilt (-5, 15, 30 degree)	—

Countries

Japan

Contacts

Public ContactTomokazu Kato

Nihon University School of Medicine Division of Hygiene, Department of Social Medicine

kato.tomokazu@nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026