Retrospective exploratory clinical study to identify epileptogenic foci by statistical analysis of electrocorticographic signals during general anesthesia in patients with intractable epilepsy (observational study)

Retrospective exploratory clinical study to identify epileptogenic foci by statistical analysis of electrocorticographic signals during general anesthesia in patients with intractable epilepsy (observational study) - Retrospective exploratory clinical study to identify epileptogenic foci by statistical analysis of electrocorticographic signals during general anesthesia in patients with intractable epilepsy (observational study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044846

Enrollment

Registered

2021-07-13

Start date

2021-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

refractory epilepsy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with refractory epilepsy who are scheduled for focal resection after placement of intracranial electrode 2) Patients with obvious abnormalities in MRI in the area expected to show epileptogenicity 3) Patients with ASA-PS (American association of anesthesia physical status) 1-2 4) Patients in NCNP hospital 5) Patients achieving ILAE class 1 outcome at least six months after surgical resection

Exclusion criteria

Exclusion criteria: 1) Patients who cannot be used sevoflurane 2) Patients who cannot be used propofol 3) The case an anesthetic other than sevoflurane, propofol, remifentanil, rocuronium is used during EEG measurement 4) Patients with ASA-PS3 or higher 5) Patients with epilepsy surgery not intended for radical surgery 6) The case does not agree with the prescribed bank consent 7) Other persons whom representative of this study consider inappropriate 8) Patients achieving ILAE class 2 or higher outcome at least six months after surgical resection

Design outcomes

Primary

Measure	Time frame
MI value at each anesthesia stage and each intracranial electrode. The ECoG analysis period was divided into the following five anesthetic stages: [1] baseline wakefulness before the anesthetic induction; [2] first 1/3; [3] middle 1/3; [4] last 1/3 periods between the sevoflurane initiation and its concentration reaching 2.0 MAC; [5] sevoflurane 2.0 MAC maintenance.	—

Secondary

Measure	Time frame
MI value at given anesthesia stage and given intracranial electrode when the epileptigenic region and the non-epileptic region are classified	—

Countries

Japan

Contacts

Public ContactKeiko Wada

National Center of Neurology and Psychiatry Department of Anesthesiology

keikotoki@ncnp.go.jp042-341-2712

Outcome results