Pancreatic ductal adenocarcinoma ten millimeter or less in diameter High-grade Pancreatic intraepithelial neoplasia (PanIN)
Conditions
Interventions
None listed
Sponsors
Oita San-ai Medical Center
Department of Gastroenterology and Hepatology, Kindai University Department of Gastroenterology, Tenri Hospital Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious disease Center Komagome Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with lesions which were histopathologically diagnosed from resected specimen of pancreas as high-grade PanIN without invasive cancer. 2. Patietnts with invasive PDAC 10mm or less in diameter (10mm-PDAC); whose diameter was calculated on histopathological specimen. 3. Patients with lesions which were strongly suspected as a high-grade PanIN lesion but with no evidence of high-grade PanIN or PDAC were also enrolled. In particular, the lesions that histopathologically diagnosed from resected specimen with no evidence of high-grade PanIN, or these with negative results on pancreatic juice cytology at least once and no change on various imaging modalities during more than 3 years follow-up period were defined as non-malignant lesions.
Exclusion criteria
Exclusion criteria: Patients with high-grade intraductal papillary mucinous neoplasm (IPMN), intraductal papillary mucinous carcinoma, and 10mm-PDAC which was treated by preoperative chemotherapy were excluded. In all lesions, the cases with technical difficulties with processing movie files were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is clarifying characteristic EUS-signs in diagnosis of high-grade PanIN, 10mm-PDAC, and non-malignant pancreatic duct irregularity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is to evaluate diagnostic performance of EUS-signs. In addition, intra- and inter-observer agreement of EUS-signs was also analyzed in blind review sessions. | — |
Countries
Japan
Contacts
Public ContactRyota Sagami
Oita San-ai Medical Center Department of Gastroenterolgoy
Outcome results
None listed