Proton-pump inhibitor use and risk of gut-origin bloodstream infection: a hospital-based case-control study

Proton-pump inhibitor use and risk of gut-origin bloodstream infection: a hospital-based case-control study - PPI use and risk of gut-origin BSI: a hospital-based case-control study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044753

Enrollment

309

Registered

2021-07-05

Start date

2021-04-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gut-origin bloodstream infection

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients aged 20 years and older who had inpatient treatment for bloodstream infection with 2 sets of positive blood culture in Ichinomiya-Nishi hospital in 2019

Exclusion criteria

Exclusion criteria: Patients under 20 years old were excluded. Patients who disagreed with enrollment of the study under the opt-out model were excluded. When patients had two or more episodes of bloodstream infections, only the first episode was included in the study.

Design outcomes

Primary

Measure	Time frame
Odds ratio of gut-origin bloodstream infection among PPI users and non-users as well as its 95% confidence interval adjusted for confounding factors	—

Secondary

Measure	Time frame
In a sensitivity analysis that excluded individuals who did not have sufficient examination to find infectious focus, we calculated odds ratio of gut-origin bloodstream infection among PPI users and non-users as well as its 95% confidence interval adjusted for confounding factors.	—

Countries

Japan

Contacts

Public ContactShintaro Hayashi

Ichinomiya-Nishi Hospital Department of gastroenterology

sntr.hayashi@gmail.com0586480077

Outcome results