A prospective observational study to elucidate the dynamics of microparticles and their pathophysiological role in septic disseminated intravascular coagulation syndrome.

A prospective observational study to elucidate the dynamics of microparticles and their pathophysiological role in septic disseminated intravascular coagulation syndrome. - A prospective observational study to elucidate the dynamics of microparticles and their pathophysiological role in septic disseminated intravascular coagulation syndrome.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044745

Enrollment

100

Registered

2021-08-01

Start date

2021-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with sepsis diagnosed by Sepsis-3 admitted to Tohoku University Hospital

Exclusion criteria

Exclusion criteria: 1) Cases for which consent was not obtained from the patient or the patient's next of kin 2) Patients requiring mechanical assisted circulation (IABP, ECMO, LVAD) 3) Patients requiring acute blood purification therapy prior to the start of the study 4) Patients with infection more than 7 days prior to study enrollment or with unknown onset of infection 5) Pregnant

Design outcomes

Primary

Measure	Time frame
The primary endpoint was the amount of Tissue factor bearing microparticles (TF banding MPs) at the first blood draw in the DIC and non-DIC groups.	—

Secondary

Measure	Time frame
Comparison of the production of other MPs (monocyte-derived, endothelial cell-derived, platelet-derived, etc.) between DIC and non-DIC groups. Thrombin generation study.	—

Countries

Japan

Contacts

Public ContactYusuke Takei

Tohoku University Hospital department of Anesthesiology and preoperative medicine

yusuke.takei.a3@tohoku.ac.jp022-717-7321

Outcome results