Elucidation of the impact of malocclusion and it's treatment on brain blood flow.

Elucidation of the impact of malocclusion and it's treatment on brain blood flow. - Elucidation of the impact of malocclusion and it's treatment on brain blood flow.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044742

Enrollment

150

Registered

2021-07-03

Start date

2021-07-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malocclusion (jaw deformity)

Interventions

surgical orthodontic treatment (treatment period: about 2.5-year) no treatmen (normal occlusion)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) no systemic illness (2) no orthodontic treatment history (3) no symptons on temporomandibular joint, masticatory muscles, and tooth (4) Right-handed

Exclusion criteria

Exclusion criteria: (1) have congenital diseases (2) have mental and psychological illness

Design outcomes

Primary

Measure	Time frame
We measure the brain blood flow and cognitive function of the patient with malocclusion (jaw deformity), and analyze the relationship among occlusal function, brain blood flow, and cognitive function. In addition, to compare the before and after orthodontic treatment, we clarify whether orthodontic treatment give any improvement on brain blood flow and cognitive function or not. In this research project, we assess; (1) cross-sectional study between normal occlusion group and malocclusion group, (2) cross-sectional study among the different time points in malocclusion group, (3) longitudinal study for elucidating the intra-patient change in brain blood flow and cognitive function. We examine at the following time points; (1) before orthodontic treatment (2) before jaw surgery (3) at debonding (4) during maintenance period	—

Measure

Time frame

We measure the brain blood flow and cognitive function of the patient with malocclusion (jaw deformity), and analyze the relationship among occlusal function, brain blood flow, and cognitive function. In addition, to compare the before and after orthodontic treatment, we clarify whether orthodontic treatment give any improvement on brain blood flow and cognitive function or not. In this research project, we assess; (1) cross-sectional study between normal occlusion group and malocclusion group, (2) cross-sectional study among the different time points in malocclusion group, (3) longitudinal study for elucidating the intra-patient change in brain blood flow and cognitive function. We examine at the following time points; (1) before orthodontic treatment (2) before jaw surgery (3) at debonding (4) during maintenance period

—

Countries

Japan

Contacts

Public ContactHiroyuki Kanzaki

Tsurumi University Department of orthodontics School of Dental Medicine

kanzaki-h@tsurumi-u.ac.jp045-580-8507

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Elucidation of the impact of malocclusion and it&#39;s treatment on brain blood flow.