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Effects of intravenous administration of magnesium sulfate in propofol-based sedation for ERCP in elderly patients: a randomized, double-blind, placebo-controlled study

Effects of intravenous administration of magnesium sulfate in propofol-based sedation for ERCP in elderly patients: a randomized, double-blind, placebo-controlled study - intravenous magnesium sulfate for ERCP sedation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000044737
Enrollment
80
Registered
2021-07-02
Start date
2021-08-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inpatients aged 65 to 79 years who were scheduled for ERCP were recruited into the study.

Interventions

In group M, 40 mg/kg magnesium sulfate diluted with normal saline to a total volume of 100 ml was administered for 15 minutes prior to the beginning of the procedure. An initial bolus dose of 1 mg/kg

Sponsors

Department of Anaesthesiology, People's Hospital of Chongqing Banan District
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: After obtaining written informed consent, adult patients of American Society of Anesthesiologists (ASA) physical status I through III aged between 65 and 79 years of either sex scheduled for ERCP under sedation were included in this study.

Exclusion criteria

Exclusion criteria: 1, a history of adverse events with prior sedation; 2, known hypersensitivity to any of the drugs that would be used in the study; 3, patients with ASA Class 4 or 5; 4, pre-existing hypoxemia (SpO2 < 90%); 5, hypotension (systolic blood pressure < 90mmHg) or uncontrolled hypertension (systolic blood pressure > 170mmHg, diastolic blood pressure > 100mmHg); 6, severe cardiac, renal, neurological, or liver diseases; 7, patients who had taken any sedative drug within the previous 24 hours and those who refused participation;

Design outcomes

Primary

MeasureTime frame
The primary outcomes was propofol requirements.

Countries

Asia(except Japan)

Contacts

Public Contactjie Chen

People's Hospital of Chongqing Banan District Department of Anaesthesiology

cjandsh@tmmu.edu.cn+81-086-23-66234145

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026