aspiration pneumonia
Conditions
Interventions
Intravenous administration of radioligand [15O]H2O followed by nebulizer-mediated inhalation of saline and 10% tartaric acid solution to induce cough and suppress cough by nebulizer-mediated inhalatio
Sponsors
Hamamatsu university school of medicine Hamamatsu city rehabilitation hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy male, 20 years of age or older, right hand dominant.
Exclusion criteria
Exclusion criteria: (1) Patients with epilepsy or complications from a serious disease, or those who have a history of epilepsy or complications from a serious disease and are judged by the physician as the researcher to be inappropriate for this study. (2) Those who have a history of habitual smoking. (3) Those who are dependent on alcohol. (4)Those who have suffered from neuropsychiatric disease, neuromuscular disease, head and neck disease, respiratory disease, or allergic disease (including hay fever and atopy) in the past. (5) Patients with a history of medication (6) Those who cannot undergo MRI (pacemakers, those with internal metal (brain clips, bolts, etc.), those with tattoos (including tattoos and artistic makeup), those with claustrophobia, etc.) (7) Those who have participated in nuclear medicine examinations of other healthy volunteers within one year. (8) Any other person who is judged inappropriate as a research subject by the physician who is the researcher, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole brain and Region of Interest (ROI) are used to compare the brain distribution (neural activity) of [15O]H2O during resting breathing, voluntary cough, cough suppression and cough induction. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between objective parameters of cough (PEFR) and brain activity (PET, MRI images) | — |
Countries
Japan
Contacts
Public ContactTakafumi Sugi
Hamamatsu university school of medicine Department of Biofunctional Imaging
Outcome results
None listed