Evaluation and prevention of diabetic osteosarcopenia in the elderly by nutritional intervention and physical activity advice: DOS study ( Diabetic OsteoSarcopenia study in the elderly): an open, single-arm, prospective, interventional study.

Evaluation and prevention of diabetic osteosarcopenia in the elderly by nutritional intervention and physical activity advice: DOS study ( Diabetic OsteoSarcopenia study in the elderly): an open, single-arm, prospective, interventional study. - DOS study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044687

Enrollment

Registered

2021-06-28

Start date

2021-06-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes, osteoporosis, sarcopenia

Interventions

1.nutritional intervention duration of intervention:18 months frequency of intervention:4 2.physical activity advice duration of intervention:18 months frequency of intervention:4

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who received sufficient explanation, and gave their informed written consent voluntarily with sufficient understanding. 2. Patients aged 75 years old and over at the time of consent. 3. Patients diagnosed with type 2 diabetes based on diagnostic criteria or treatment history.

Exclusion criteria

Exclusion criteria: (1) Patients with obvious dementia or mental illness. (2) Patients using steroids. (3) Patients with hepatic disorder with a Child-Pugh classification of 7 points or higher, or renal dysfunction with a serum creatinine level of 2 mg / dL or higher. (4) Heart failure with restricted physical activity (NYHA classification II or higher). (5) Patients with significant chronic complications of diabetes (nephrosis, active proliferative retinopathy, severe autonomic neuropathy). (6) Patients with an infectious disease corresponding to SIRS (systemic inflammatory response syndrome) or trauma with an AIS (abbreviated injury scale) score of 4 or higher. (7) Patients who are judged to have incurable cancer. (8) Patients with a cardiac pacemaker or implantable cardioverter-defibrillator, etc. (9) Patients with motor paralysis of limbs due to central nervous system disease. (10) Patients who are judged to be inappropriate for this clinical study by the person in charge of research or the research coordinator.

Design outcomes

Primary

Measure	Time frame
Improvement rate of endpoints for sarcopenia, osteoporosis, diabetes, nutritional status, and fatty liver after nutritional guidance and physical activity advice	—

Countries

Japan

Contacts

Public ContactTakeshi Takayanagi

Fujita Health University School of Medicine Department of Endocrinology, Diabetes and Metabolism

haratake@fujita-hu.ac.jp0562-93-9242

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026