Correlation between effectiveness and blood concentration of lacosamide internal use for focal epilepsy

Correlation between effectiveness and blood concentration of lacosamide internal use for focal epilepsy - Correlation between efficacy and blood concentration of Lacosamine

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044614

Enrollment

Registered

2021-09-01

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: children with focal epilepsy onset in childhood children who developed from birth to under 16 years of age children with good adherence Children who can accurately report the details and frequency of epileptic seizures, or children who have own guardian who can report them.

Exclusion criteria

Exclusion criteria: children who cannot measure blood levels when the patient or their guardian refuses to take lacosamide children who have difficulty continuing treatment due to the side effects of lacosamide

Design outcomes

Primary

Measure	Time frame
seizure frequency reduction rate peak blood level of lacosamide correlation coefficient These results are verified by Spearman's rank correlation coefficient to determine the correlation.	—

Secondary

Measure	Time frame
seizure frequency reduction rate peak blood level of lacosamide p-value When the correlation is low in the primary outcome, the effective group (seizure frequency reduction rate of 50% or more) and the ineffective group (less than 50%) are compared, and a significant difference in blood concentration is confirmed.	—

Countries

Japan

Contacts

Public ContactToshiyuki Iwasaki

Kawasaki Municipal Tama Hospital pediatrics

tiwasaki52@gmail.com0449338111

Outcome results