Patients with known or suspected chronic coronary artery disease
Conditions
Interventions
15O-H2O myocardial perfusion PET
Sponsors
Department of Radiology, Mie University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with chronic coronary artery disease or suspected coronary artery disease who are referred for cardiac MRI following the clinical indication. (2) Adult patients aged 20 years or older at the time of MRI (3) Patients who have given written informed consent for participation in the study, including 15O-H2O myocardial perfusion PET.
Exclusion criteria
Exclusion criteria: 1) Patients with contraindications to the use of gadolinium contrast media 2) Patients with contraindications to ATP 3) Patients with severe claustrophobia 4) Patients with arrhythmias such as persistent atrial fibrillation or premature ventricular contraction 5) Patients who are unable to follow instructions to breath holding 6) Patients in an extremely poor general condition 7) Women who are pregnant or with suspected pregnancy 8) Patients with devices that are not MRI compatible 9) Patients with MRI-compatible devices (pacemakers, ICDs) that affect the quality of the MRI images 10) Patients who have had a cardiovascular event, revascularization procedure, change or addition of medication between cardiac MRI and myocardial perfusion PET. 11) Patients who are judged by the principal investigator or sub-investigator to be unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In a pilot group, myocardial blood flow (MBF) determined by MRI will be compared with 15O-H2O PET to determine whether there are systematic errors in MBF. If a systematic error in MBF is found in the pilot group, a correction formula will be calculated and validated in a different group (validation group). | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Myocardial perfusion reserve (MPR) will be compared between quantitative myocardial perfusion MRI and 15O-H2O PET. (2) Diagnostic value of MBF and MPR determined by quantitative myocardial perfusion MRI will be investigated using coronary angiography, fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) as references, in patients undergoing coronary angiography. | — |
Countries
Japan
Contacts
Public ContactMasaki Ishida
Mie University Hospital Department of Radiology
Outcome results
None listed