Effects of hypervolemia with hemodilution due to rapid fluid infusion on intracranial pressure in human volunteers

Effects of hypervolemia with hemodilution due to rapid fluid infusion on intracranial pressure in human volunteers - Effects of rapid fluid infusion on intracranial pressure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044606

Enrollment

Registered

2021-06-21

Start date

2021-06-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Not applicable(healthy male volunteers, opt-out)

Interventions

Control is pre-infusion measurement in a supine position. The first intervention is that 15 mL/kg of normal saline was administered at a rate of 100 mL/min in a supine (named NS-15). The second in

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The participants who were taken part in the original study performed by Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine in 2005. The written informed consent was obtained in the original study to investigate the effects of changes in blood volume on circulatory regulation.

Exclusion criteria

Exclusion criteria: Participants who desire withdraw from the present study via opt-out.

Design outcomes

Primary

Measure	Time frame
Noninvasive ICP (nICP)	—

Secondary

Measure	Time frame
Cerebral artery compliance CBF pulsatility index (PI)	—

Countries

Japan

Contacts

Public ContactKen-ichi Iwasaki

Nihon University School of Medicine Department of Social Medicine, Division of Hygiene

iwasaki.kenichi@nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026