superficial esophageal cancer
Conditions
Interventions
None listed
Sponsors
Nagoya City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Either "histologically confirmed high grade intraepithelial neoplasia, squamous cell carcinoma, or adenocarcinoma" or "endoscopically diagnosed as esophageal cancer" 2.Clinically diagnosed as T1 stage, superficial esophageal cancer 3.20 years old =< age =< 85 years old 4.PS:0-2 5.Plan of endoscopic or surgical tumor resection 6.Written informed consent
Exclusion criteria
Exclusion criteria: 1.Patients with other active malignancies 2.Difficulty of tumor resection due to poor physical condition 3.Patients who will be treated by radiation therapy, chemotherapy or argon plasma coagulation therapy. 4.Patients with severe mental disorder and dementia 5.Investigator's decision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of the serum biomarker for the stage diagnosis (squamous cell carcinoma) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Accuracy of the serum biomarker for the stage diagnosis (adenocarcinoma) 2. Sensitivity, specificity, PPV and NPV of the serum biomarker for surgical indication 3. Comparison between the serum biomarker and endoscopic diagnosis for the accuracy of the stage diagnosis 4. Accuracy, sensitivity, specificity, PPV and NPV by combining the serum biomarker and endoscopic diagnosis 5. Comparison between the combination biomarker and endoscopy alone for the accuracy of the stage diagnosis 6. Assessment of the tissue biomarkers | — |
Countries
Japan
Contacts
Public ContactYusuke Okuda
Nagoya City University Graduate School of Medical Sciences Department of Gastroenterology and Metabolism
Outcome results
None listed