Healthy adults
Conditions
Sponsors
Morinaga & Co.,Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Healthy male/female subjects ranging in age from 20 to 60, at informed consent. (2)Those who feel coldness in their hands and feet on a daily basis. (3)Subjects whose BMI is less than 18.5 or over 30.0 kg/m^2. (4)Subjects who can give informed consent to take part in this trial, after being provided with an explanation of the protocol detail.
Exclusion criteria
Exclusion criteria: (1)Subjects who had or suspected infectious disease such as COVID-19, or who had close contact with a COVID-19 patient. (2)Subjects who have current medical treatments, or who are planning some kind of treatment the study period. (3)Subjects who constantly use medicines that may affect test results.(cephem antibiotics such as Cefaclor, Cefotiam, Cefdinir, Anti-alcoholic drugs such as Disulfiram, Cyanamide etc.).Those who take health foods and supplements (turmeric, ornithine, etc.) daily, and those who may take or take them during the test period. (4)Subjects who have wound or inflammation around the measurement area. (5)Smokers or subjects who smoked within a year. (6)Subjects who cannot intake the foods containing cacao (because of preference, headache, etc.) (7)Subjects who are aware of the severity such as menstrual irregularity, menstrual pain, menopause. (8)Subjects who have irregular eating habits or irregular life rhythm (shift worker, midnight worker). (9)Pregnant, possibly pregnant, lactating women. (10)Subjects who have current medical history or past medical history of high blood pressure. (11)Subjects with previous/current medical history of serious disease in heart, liver, kidney, digestive organ etc. (12)Subjects with excessive alcohol intakes. (13)Subjects having drug/food allergy. (especially milk, soy, pork) (14)Subjects who cannot remove their manicure or false nail on test-day. (15)Subjects who are now under the other clinical trials with some kind of medicine/food, or participated in those within 4 weeks prior to this study, or are planning to join those after giving informed consent to take part in this study. (16)Others who have been determined as ineligible for participation, according to the principal/sub investigator's opinion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood flow (skin blood flow) Body surface temperature (skin surface temperature) | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS questionnaire | — |
Countries
Japan
Contacts
Public ContactHiroyuki Inagaki
Morinaga & Co.,Ltd Health Science and Research Center, R&D institute
Outcome results
None listed