A prospective observational study of changes in blood levels of thiamine, ascorbic acid, cortisol, and copeptin in patients with sepsis

A prospective observational study of changes in blood levels of thiamine, ascorbic acid, cortisol, and copeptin in patients with sepsis ;(Thiamine, Ascorbic acid, Cortisol, and Copeptin evaluation) study - TACTIC study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044490

Enrollment

200

Registered

2021-08-01

Start date

2021-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with sepsis by sepsis-3 at the Emergency department.

Exclusion criteria

Exclusion criteria: Patients already diagnosed with sepsis at another hospital Patients who did not consent to this study Patients after cardiopulmonary arrest resuscitation Patients judged to be ineligible by attending physicians For patients who declined aggressive treatment by the third day of hospitalization, data after the decline of treatment will not be used.

Design outcomes

Primary

Measure	Time frame
28-days mortality	—

Secondary

Measure	Time frame
Changes in SOFA score on the 4th day Hospital mortality Refractory shock (inadequate hemodynamic response to noradrenalin administration)	—

Countries

Japan

Contacts

Public ContactDaisuke Kudo

Tohoku University Graduate School of Medicine Division of Emergency and Critical Care Medicine

information@emergency-medicine.med.tohoku.ac.jp022-717-7489

Outcome results