Mycoplasma
Conditions
Interventions
Antibiotics + Prednisolone 0.5 mg/kg/dose(three times daily for 5 days)
Antibiotics
Sponsors
Tokyo Metropolitan Children's Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Men and women under the age of 18 2) Mycoplasma positive by nucleic acid amplification test or immunochromatography 3) Those who had pneumonia on chest X-ray or chest CT, had respiratory symptoms, were diagnosed with acute pneumonia, and were hospitalized. 4) Axillary body temperature of 38 degrees or higher at admission 5) Those who have received sufficient explanation for participating in this study, and have obtained the voluntary consent of the person or his / her substitute after sufficient understanding.
Exclusion criteria
Exclusion criteria: 1) Intravenous or oral steroids were given after a series of symptoms that caused hospitalization were observed (regardless of the use of topical steroids and inhaled steroids). 2) Those with the following pre-existing conditions Bronchial asthma, immunodeficiency, congenital respiratory disease, congenital disease with abnormal hemodynamics, premature birth / low birth weight infant, post-tracheostomy, gastroesophageal reflux disease, severely handicapped child 3) Those judged to require positive pressure ventilation or intensive care management 4) Those who cannot start treatment within 24 hours after admission 5) Others that the principal investigator deems inappropriate as a research subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from case registration to fever reduction | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Time to meet all discharge criteria The discharge criteria are defined as the following three items. a)Less than 37.5 degrees lasts for 12 hours or more b)Does not require continuous infusion c)More than 12 hours have passed since the increasing oxygen demand disappeared. 2)Percentage of subjects with fever (37.5 degrees or higher) on the 3rd day of registration 3)Percentage of subjects who meet the discharge criteria on the 7th day of registration 4)Subpopulation analysis of the following items (LDH is more than 480 U/L presence / absence, oxygen administration presence / absence at the time of registration, severity classification) Fever period Time to meet discharge criteria Oxygen administration period 5)Percentage of subjects who required positive pressure management or intensive care management 6)Percentage of adverse events 7)Percentage of relapsed patients | — |
Countries
Japan
Contacts
Public ContactTakahiro Matsushima
Tokyo Metropolitan Children's Medical Center General Pediatrics
Outcome results
None listed