Comparision of Anesthetic drug combinations Bupivacaine with clonidine and Levobupivacaine with clonidine used in nerve blocks for surgeries of upper limb

A PROSPECTIVE RANDOMIZED CLINICAL STUDY TO COMPARE THE EFFICACY OF 0.25% BUPIVACAINE WITH CLONIDINE AND 0.25% LEVOBUPIVACAINE WITH CLONIDINE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR UPPER LIMB SURGERIES - A PROSPECTIVE RANDOMIZED CLINICAL STUDY TO COMPARE THE EFFICACY OF 0.25% BUPIVACAINE WITH CLONIDINE AND 0.25% LEVOBUPIVACAINE WITH CLONIDINE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR UPPER LIMB SURGERIES

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044438

Enrollment

Registered

2021-06-04

Start date

2013-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ANAESTHESIA FOR UPPER LIMB SURGERIES

Interventions

Group BC: recieved 30 ml of 0.25% Bupivacaine with 1microgram/kg Clonidine for supraclavicular brachial plexus block for upper limb surgeries Group LC: recieved 30 ml of 0.25% Levoupivacaine with 1mic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients aged between 18 to 60 years of either sex. 2.ASA physical status I-II 3.Elective upper limb surgeries

Exclusion criteria

Exclusion criteria: 1.Patient refusal for procedure 2.Any bleeding disorder or patient on anticoagulants 3.Neurological deficits involving brachial plexus 4.Patients with allergy to local anaesthetics 5.Local infection at the injection site 6.Patients on any adrenoreceptor agonist or antagonist therapy 7.Patients weighing less than 35kgs 8.Body mass index >35 9.Pregnant women

Design outcomes

Primary

Measure	Time frame
Measure the Onset and duration of action between combination of 0.25% Bupivacaine with Clonidine and 0.25% Levobupivacaine with Clonidine in Supraclavicu;ar Brachial plexus block for upper limb surgeries. Onset was measured every minute after giving supraclavicular brachial plexus block Duration was measured until complete recovery from supraclavicular brachial plexus block using Bromage scale	—

Secondary

Measure	Time frame
1. Hemodynamic changes mainly systolic blood pressure, diastolic blood pressure, Mean arterial blood pressure and Peripheral oxygen saturation SpO2 are measured Intraoperatively every 5 minutes and Postoperatively every hourly upto 24 hours between the study groups 2.Postoperative Assessment of pain with the use of Visual analogue scale was measured every hourly upto 24 hours. 3. Occurance of any adverse events were notes	—

Measure

Time frame

1. Hemodynamic changes mainly systolic blood pressure, diastolic blood pressure, Mean arterial blood pressure and Peripheral oxygen saturation SpO2 are measured Intraoperatively every 5 minutes and Postoperatively every hourly upto 24 hours between the study groups 2.Postoperative Assessment of pain with the use of Visual analogue scale was measured every hourly upto 24 hours. 3. Occurance of any adverse events were notes

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Countries

Asia(except Japan)

Contacts

Public ContactABHISHEK R

K.V.G. MEDICAL COLLEGE AND HOSPITAL DEPARTMENT OF ANAESTHESIOLOGY

drabhishekservices@gmail.com7795098801

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026