Healthy subjects
Conditions
Interventions
sleep in order of auditory condition and no auditory condition.
Two nights'
sleep in order of no auditory condition and auditory condition.
Sponsors
University of Tsukuba
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants will be included in the following all criteria. 1) Having no difficulty in filling out Japanese explanatory documents, consent forms, and survey forms 2) No claustrophobia and being able to stay in the examination room on the 5th floor of the Innovative Medical Research Institute, University of Tsukuba. 3) Having no sleep disorder currently being treated 4) Having no hearing impairment in daily life 5) High scores of State-Trait Anxiety Inventory - subscale scores of trait anxiety (45-80 point)
Exclusion criteria
Exclusion criteria: Participants will be excluded from the experiment based on the following criteria. 1)BMI less than 18.5 or greater than 25 2)Worked night shifts (after 10pm) 3 months prior to the experiment 3) Travel across time zones with time Difference of 3 hours or more, 3 months prior to the experiment 4) Consumes alcohol regularly (40g (2 cans of beer) or more twice a week a more) 5)Smoker 6) Consumes more than 400 mg (Based on the maximum caffeine intake of healthy adults without adverse effects [European Food Safety Authority, Health Canada],5 cups of 150mL) of coffee every day 7) MEQ score of less than 30 (extreme evening type) or greater than 70 (extreme morning type) 8) Those who cannot perceive the auditory stimulation and feel uncomfortable when listening to samples of this experiment. 9) Pregnancy or its possibility 10) Lactation 11) Those who have a disease that may change suddenly or its history 12) Those who have been treated for psychiatric disorders or sleep disorders, and those who have symptoms that are currently being treated 13)Candidates of Participants who follow all inclusion criteria, but exclusion criteria 1) -12) will be reported to psychiatrist. Psychiatrist interviews as needed to determine the unsuitable person as a subject. 14) Subjects judged by the principal investigator to be inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective anxiety using the questionnaire(State-Trait) Anxiety Inventory - subscale scores of state anxiety) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)The change of power in the slow wave activity frequency with and without auditory stimuli 2)Amplitude of slow wave 3)Sleep variables obtained by polysomnography 4)Heart rate variability 5)Electroencephalogram (EEG) 6)Electrooculogram (EOG) 7)Electromyogram (EMG) 8)Respiration 9)The changes of skin conductance change 10)Psychomotor vigilance test performance 11)Subjective sleepiness by a questionnaire (Karolinska Sleepiness Scale) 12)Subjective sleep evaluation after waking up (Oguri-Shirakawa-Azumi Sleep inventory) 13)Subjective mood and affect (Profile of Mood State 2, Positive and Negative Affect Schedule) 14)Characteristic waves of sleep EEG | — |
Countries
Japan
Contacts
Public ContactTakashi Abe
University of Tsukuba International Institute for Integrative Sleep Medicine (WPI-IIIS)
Outcome results
None listed