Study of formation and disappearance of gastrointestinal angiodysplasia that is associated with cardiovascular diseases with high shear stress

Study of formation and disappearance of gastrointestinal angiodysplasia that is associated with cardiovascular diseases with high shear stress - Study of formation and disappearance of gastrointestinal angiodysplasia that is associated with cardiovascular diseases with high shear stress

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000044141

Enrollment

305

Registered

2021-06-01

Start date

2022-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe aortic stenosis, mitral regurgitation, implantable ventricular assist device placement, obscure gastrointestinal bleeding

Interventions

A ,Aortic valve stenosis (AS) For cases of AS, EGD/CS/CE are provided as insurance medical treatment before TAVI if the condition permits, but within 1 month after TAVI for cases with poor condition

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A)Aortic stenosis with anemia (Aortic valve implantation (TAVI) cases with a catheter of hemoglobin <11.0 g / dL) 200 cases B)30 cases of mitral regurgitation with anemia (hemoglobin <11.0 g / dL) (AVWS also develops in mitral regurgitation, but hemodynamics are different from aortic stenosis. Therefore, mitral regurgitation is also targeted to determine the effect of hemodynamics.) C)LVAD implantation cases:25 cases D)Gastrointestinal bleeding of unknown cause (no obvious source of bleeding such as cancer, ulcer, inflammation, diverticulum): 50 cases

Exclusion criteria

Exclusion criteria: 1) Cases with apparently serious infections and inflammation 2) Cases with serious complications (intestinal paralysis, intestinal obstruction, etc.) 3) Instability of hemodynamics 4) After gastrointestinal surgery (Post appendectomy is OK) 5) Cases suspected of gastrointestinal stenosis 6) Advanced cancer 7) Cases where other causes of anemia, such as cancer, cancer treatment, and blood disorders, can be found 8) Cases of inflammatory bowel disease 9) Other cases that doctors deem inappropriate for this study

Design outcomes

Primary

Measure	Time frame
Perform gastrointestinal endoscopy to evaluate the presence, size, morphology, number, and site of onset of gastrointestinal angiodysplasia.	—

Secondary

Measure	Time frame
Obtain the von Willebrand factor (VWF) polymer multimer index. In addition, comprehensive hemostatic analysis of VWF antigen amount, VWF activity, PAI-1, soluble thrombomodulin, etc. will be performed.	—

Countries

Japan

Contacts

Public ContactHisanori Horiuchi

Tohoku University Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer

hisanori.horiuchi.e8@tohoku.ac.jp022-717-8463

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026