The effects of estrogen on blood coagulation, anticoagulation, and fibrinolysis in gynecologic benign diseases: A prospective study.

The effects of estrogen on blood coagulation, anticoagulation, and fibrinolysis in gynecologic benign diseases: A prospective study. - The effects of estrogen on blood coagulation, anticoagulation, and fibrinolysis in gynecologic benign diseases: A prospective study.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044081

Enrollment

120

Registered

2021-05-10

Start date

2021-05-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gynecologic benign diseases

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients who are diagnosed as uterine fibroids, adenomyosis, endometriosis, endometrial polyps, or ovarian cysts by gynecological practice with and without Gonadotropin releasing hormone agonist/antagonist. Patients during non-ovarian stimulation cycles. Patients during controlled ovarian hyperstimulation cycles.

Exclusion criteria

Exclusion criteria: Patients medicated with antiplatelets or anticoagulants. Patients affected by venous thromboembolism. Patients complicated with diseases involving platelets, coagulation, fibrinolysis, anticoagulation, or antifibrinolysis system. Patients with anemia (Hb< 8.0 g/dL). Patients after menopause. Patients with serious liver disease (or AST <= 100 U/L). Patients with severe renal disease (or serum creatinine <= 1.3 mg/dL). Pregnant women. Women during lactation.

Design outcomes

Primary

Measure	Time frame
The parameters of Rotational thromboelastometry and Endogenous thrombin potential-based activated protein C sensitivity ratio.	—

Countries

Japan

Contacts

Public ContactYusuke Todo

Hamamatsu University School of Medicine Department of Obstetrics and Gynecology

D21022@hama-med.ac.jp053-435-2309

Outcome results