Effect of ammonia-lowering therapy on covert hepatic encephalopathy: a prospective study

Effect of ammonia-lowering therapy on covert hepatic encephalopathy: a prospective study - Effect of ammonia-lowering therapy on covert hepatic encephalopathy: a prospective study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044033

Enrollment

200

Registered

2021-08-01

Start date

2021-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cirrhosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: cirrhotic patients with covert hepatic encephalopathy

Exclusion criteria

Exclusion criteria: Presence of overt hepatic encephalopathy or history of OHE in the past 4 weeks; Presence of uncontrolled hepatocellular carcinoma or other malignancies; Previous transjugular intrahepatic portosystemic shunt or shunt surgery; Active ongoing infection; History of gastrointestinal bleeding, infection or spontaneous bacterial peritonitis in the past 4 weeks; Drug or alcohol abuse in the past 4 weeks; Use of benzodiazepines, anti-epileptic or psychotropic drugs; Presence of neurological diseases; Pregnancy; Presence of severe comorbidities such as heart, respiratory, and/or renal failure

Design outcomes

Primary

Measure	Time frame
Improvement of covert hepatic encephalopathy	—

Countries

Japan

Contacts

Public ContactTatsunori Hanai

Gifu University Graduate School of Medicine Department of Gastroenterology/Internal Medicine

hanai@gifu-u.ac.jp058-230-6308

Outcome results