Impact of gut environment on the development of intestinal graft-versus-host disease, a complication of hematopoietic stem cell transplantation

Impact of gut environment on the development of intestinal graft-versus-host disease during allogeneic hematopoietic stem cell transplantation - Impact of gut environment on the development of intestinal graft-versus-host disease during allogeneic hematopoietic stem cell transplantation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000044017

Enrollment

160

Registered

2021-04-30

Start date

2021-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hematological disorders eligible for allogeneic hematopoietic stem cell transplantation

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients and their donors undergoing allogeneic hematopoietic stem cell transplantation at Yamagata University Hospital Patients and their donors who have been fully informed of the purpose of the study in the consent document approved by the Ethical Review Committee and have given their free written consent. Patients and their donors who are 20 years of age or older at the time of consent.

Exclusion criteria

Exclusion criteria: Patients with synchronous multiple cancers. Patients with a history of bowel resection. Patients who are unable to collect stool. However, if only the donor is unable to collect stool and the patient is able to collect stool, the patient will not be excluded. Other patients deemed inappropriate by the investigators.

Design outcomes

Primary

Measure	Time frame
Gut environment involved in the onset of intestinal GVHD	—

Secondary

Measure	Time frame
The gut environment involved in the severity of intestinal GVHD Intestinal environment involved in prognosis after transplantation Similarity of gut environment between patients and donors and its relation to pathogenesis and prognosis of GVHD Alterations in the gut environment during the process from autologous to donor hematopoiesis Comparison of the gut environment in intestinal GVHD and inflammatory bowel disease Relationship between endoscopic findings and severity of intestinal GVHD	—

Measure

Time frame

The gut environment involved in the severity of intestinal GVHD Intestinal environment involved in prognosis after transplantation Similarity of gut environment between patients and donors and its relation to pathogenesis and prognosis of GVHD Alterations in the gut environment during the process from autologous to donor hematopoiesis Comparison of the gut environment in intestinal GVHD and inflammatory bowel disease Relationship between endoscopic findings and severity of intestinal GVHD

—

Countries

Japan

Contacts

Public ContactYu Sasaki

Faculty of Medicine, Yamagata University Department of Gastroenterology

y-sasaki@med.id.yamagata-u.ac.jp0236285309

Outcome results