An exploratory study on the association between squamous cell carcinoma occurrence and upper gastrointestinal microbiota in patients with laryngopharyngeal cancer

An exploratory study on the association between squamous cell carcinoma occurrence and upper gastrointestinal microbiota in patients with laryngopharyngeal cancer - An exploratory study on the association between squamous cell carcinoma occurrence and upper gastrointestinal microbiota in patients with laryngopharyngeal cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000043963

Enrollment

Registered

2021-04-18

Start date

2020-06-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laryngopharyngeal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients with a current or past history of laryngopharyngeal cancer and healthy subjects

Exclusion criteria

Exclusion criteria: 1.Patients whom the principal investigator determined to be inappropriate to participate in the study 2. Patients under the age of 20 3. Patients who are pregnant 4. Patients who underwent antibiotic treatment within a month 5. Patients who took proton pump inhibitors within a month

Design outcomes

Primary

Measure	Time frame
Microbial profile between the patients with laryngopharyngeal cancer and healthy subjects 1) Relative abundance at the level of phylum/genus/OTU level 2) Alfa-diversity [Shannon index, Chao1 index, ACE, Number of observed OTUs] 3) Beta-diversity [weighted and unweighted UniFrac distance-based analysis]	—

Countries

Japan

Contacts

Public ContactYuko Hara

The Jikei University School of Medicine Department of Endoscopy

yukohara0526@yahoo.co.jp0334331111

Outcome results