Gastroesophageal reflux disease
Conditions
Interventions
Esophageal high-resolution impedance manometry for one hour and multiple intraluminal impedance-pH monitoring for 24hours
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Participants aged between 20-70 years of either gender without reflux symptoms (2)Performance Status (ECOG): 0-1 (3)Ability to understand the study information sheet and instructions and able to provide informed consent.
Exclusion criteria
Exclusion criteria: (1) Taking NSAIDs, steroids, immunosuppresive medications (2) Prior abdominal surgery (3) Prior chemotherapy (4) Diabetes and collagen disease (5) Taking acid suppressive medications and prokinetics (6) Prior allergic reaction to Xylocain (7) Difficulty in inserting a catheter due to narrow nasal cavity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Esophageal acid exposure in MII-pH | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total reflux episodes including acid and non-acid in MII-pH 2. Total supragastric belching (SGB) episodes in MII-pH 3. Transient lower esophageal sphincter relaxation (TLESR) episodes in a postprandial period in HRIM 4. TLESR with reflux episodes in a postprandial period in HRIM 5. Postprandial SGB episodes in MII-pH 6. Postprandial rumination episodes in HRIM | — |
Countries
Japan
Contacts
Public ContactKenichiro Nakagawa
Tohoku Univerisity Gastroenterology
Outcome results
None listed