Healthy subjects
Conditions
Interventions
Five pre-menopausal women without using any feminine products
Fifteen pre-menopausal women using feminine soap and cream for 4 weeks
Fifteen pre-menopausal women using feminine soap, cream and Lactoba
Sponsors
Aging Care Division Advanced Medical Care Co. Ltd.
Hamamatsucho Hamasite Clinic Shinkokai Medical Corporation
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Thirty five healthy pre-menopausal women (20-49 years of age) Thirty five healthy postmenopausal women (50-75 years of age) -Who give consent on the research -Postmenopausal women (natural absence of menstruation over at least 12 months since the last menstrual period or FSH >= 25mIU/mL, E2<20pg/mL excluding surgical menopause
Exclusion criteria
Exclusion criteria: 1. Those under treatment for urinary tract infection 2. Those under treatment for urinary stone, hydronephrosis, renal tumor, etc. 3. Those who have taken antibiotics or steroids 2 weeks before the study or during the study 4. Those who have skin lesions on skin and mucosa of external genitalia or gynecological diseases such as vaginitis (except from asymptomatic atrophic vaginitis) 5. Those considered ineligible by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in vaginal flora types, compositions, diversity index and clusters before and after the intervention at 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the following changes before and after the intervention at 4 weeks 2. Vaginal pH 3. Lifestyle habits, well being, climacteric symptoms, overactive bladder symptoms One time evaluation before the intervention 4. Vaginal maturation index 5. Ovarian function(E2, FSH) 6. Gut micro-flora 7. Equol producer status | — |
Countries
Japan
Contacts
Public ContactShoji Isono
Advanced Medical Care Co. Ltd. Aging Care Division
Outcome results
None listed