multiple sclerosis
Conditions
Interventions
A standard solution of lactulose (5 g) and mannitol (2 g)in 500 mL of tap water was ingested before bed. Urine was collected the following morning in a container (with 5 mL of thymol solution).
Sponsors
Department of Neurology and Neurological Science, Tokyo Medical and Dental University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: MS and related disorders (neuromyelitis optica spectrum disorders (NMOSD) and clinically isolated sydrome) will be included. MS is diagnosed by McDonald's criteria 2017 and NMOSD is diagnosed by Wingerchuk's criteria 2015.
Exclusion criteria
Exclusion criteria: Persons who have 1. pace makers or magnetic metals 2. claustrophobia 3. unstable general condition and vital signs 4. difficulty in informed consent 5. cancers or inflammatory bowel disease 6. diabetes mellitus , pregnant women and persons who is not suitable for the participants according to the doctor's decision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between the rate of brain atrophy over 48 months and intestinal permeability measured at baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Association between intestinal permeability at baseline and disease subtypes, disability, cognition, brain volume and disease modifying therapy | — |
Countries
Japan
Contacts
Public ContactHiroaki Yokote
Nitobe Memorial Nakano General Hospital Department of Neurology
Outcome results
None listed