Inhibitory effect of general anesthetics (remimazolam) on metabolism

Inhibition of Metabolism by a General Anesthetic (Remimazolam) Using Indirect Calorimetry -A Prospective Observational Study- - Inhibition of Metabolism by a General Anesthetic (Remimazolam) Using Indirect Calorimetry -A Prospective Observational Study-

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000043879

Enrollment

Registered

2021-04-10

Start date

2021-04-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical cases undergoing general anesthesia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing general anesthesia with remimazolam under endotracheal intubation control in our operating room who have given consent to participate in the study.

Exclusion criteria

Exclusion criteria: Patient factors: allergy to any of the components of remimazolam, history of central nervous system disease (cerebral infarction, cerebral hemorrhage, etc.), neuromuscular disease (myasthenia gravis, etc.), uncontrolled heart failure or respiratory failure, renal failure (serum creatinine > 2 mg/dl), liver failure (AST/ ALT > 2.5 ULN), and patients who do not consent to the study. ALT>2.5ULN), and those who do not consent to the study. Surgical factors: surgery requiring repositioning or isolated lung ventilation, head and neck surgery, emergency surgery

Design outcomes

Primary

Measure	Time frame
Compare oxygen consumption, carbon dioxide production, and total energy expenditure before and after induction of general anesthesia.	—

Secondary

Measure	Time frame
Compare biological signs (blood pressure, heart rate, cardiac output, BIS) and oxygen supply/demand balance indices (CaO2, DO2, ERO2) before and after induction of general anesthesia. Comparison of drug effect site concentrations (remimazolam, remifentanil, fentanyl, volume of supplemental fluid, hypertensive drugs, etc.) after induction of general anesthesia. Compare the respiratory status of spontaneous breathing (volume and frequency of breathing) and ventilator settings during general anesthesia (volume and frequency of breathing, maximum airway pressure, compliance, and dead space volume). Factors contributing to the difference in EE before and after induction will be investigated by multivariate analysis.	—

Measure

Time frame

Compare biological signs (blood pressure, heart rate, cardiac output, BIS) and oxygen supply/demand balance indices (CaO2, DO2, ERO2) before and after induction of general anesthesia. Comparison of drug effect site concentrations (remimazolam, remifentanil, fentanyl, volume of supplemental fluid, hypertensive drugs, etc.) after induction of general anesthesia. Compare the respiratory status of spontaneous breathing (volume and frequency of breathing) and ventilator settings during general anesthesia (volume and frequency of breathing, maximum airway pressure, compliance, and dead space volume). Factors contributing to the difference in EE before and after induction will be investigated by multivariate analysis.

—

Countries

Japan

Contacts

Public ContactKenya Yarimizu

Yamagata University Medical School Hospital Department of Anesthesiology

yarimizu.kenya@gmail.com0236285400

Outcome results