Prospective study for postoperative motor and cognitive improvement by maintaining mild hypercapnia during general anesthesia

Randomized controlled trial for postoperative motor and cognitive improvement by maintaining mild hypercapnia during general anesthesia - Effects of mild hypercapnia on postoperative motor and cognitive function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000043793

Enrollment

120

Registered

2021-04-01

Start date

2021-04-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing open abdominal surgery under general anesthesia

Interventions

mild hypercapnia normocapnia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: open abdominal surgery patient

Exclusion criteria

Exclusion criteria: 1. Laparoscopic surgery patients 2. Patients with pulmonary hypertension 3. Obstructive lung disease 4. Patients with congenital heart disease 5. Patients with high intracranial pressure 6.Patients with other pathological conditions exacerbated by hypercapnia 7.Patients who used benzodiazepines the day before or during surgery 8.Patients diagnosed with cognitive dysfunction before surgery 9.Patients with difficult epidural insertion 10.Patients whose grip strength measurement is difficult due to physical reasons 11.Emergency surgery 12.State with data loss 13.Patients judged by the principal investigator to be inappropriate as subjects

Design outcomes

Primary

Measure	Time frame
Grip strength fluctuation rate on the 7th day after surgery (grip strength on the 7th day after surgery / preoperative grip strength)	—

Secondary

Measure	Time frame
Grip strength the day after surgery, incidence of delirium, cognitive function score 7 days after surgery	—

Countries

Japan

Contacts

Public ContactKyongsuk Son

Chiba university hospital Department of anesthesiology

adya5599@chiba-u.jp0432227171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026