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Multi-institutional prospective observational study of post-treatment outcome for entire circumferential superficial esophageal cancer

Multi-institutional prospective observational study of post-treatment outcome for entire circumferential superficial esophageal cancer - Outcome study for entire circumferential superficial esophageal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000043763
Enrollment
200
Registered
2021-03-27
Start date
2021-05-24
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

None listed

Sponsors

National Cancer Center Hospital East, Kashiwa, Chiba, Japan
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Clinically diagnosed as esophageal squamous cell carcinoma 2. Lesions mainly located in the cervical, thoracic, and abdominal esophagus 3. The lesion's depth of invasion is clinically diagnosed as EP/LPM or MM/SM1 4. No lymph node metastasis and no distant metastasis (cN0M0) 5. The entire circumferential lesion or sub-circumferential lesion (only in the case that become or expected to become the entire circumferential mucosal defect after ESD) 6. All multiple lesions are clinically diagnosed as MM/SM1 and spreading to less than 3/4 circumference of esophageal wall 7. Plaaned to perform with ESD, OPE, CRT, or RT in two months, or already performed within two weeks 8. No prior treatment of radiation therapy to the cervical chest, lung, or mediastinum field for any malignancies 9. No prior treatment for esophageal cancer, except for complete resection by EMR/ESD (shaollower than pT1a-MM without lympovascular invasion) and fulfilling the following (1) and (2) (1) The main lesion is located within 20 mm from the center of the scar after prior EMR/ESD (2) The ordinally endoscopy (diameter of 9.6-10.4 mm) could not pass the esophagus deu to the scar after prior EMR/ESD 10. 20 years or older 11. Written informed consent

Exclusion criteria

Exclusion criteria: Synchronous or metachronous (within 1 year) malignancy

Design outcomes

Primary

MeasureTime frame
Overall survival

Countries

Japan

Contacts

Public ContactTomohiro Kadota

National Cancer Center Hospital East, Kashiwa, Chiba, Japan Department of Gastroenterology and Endoscopy

tkadota@east.ncc.go.jp04-7133-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026