Examination of structural remission and reduction of drug free of filgotinib in rheumatoid arthritis patients whose MTX alone or MTX combined with biologics are non responsive.

Examination of structural remission and reduction of drug free of filgotinib in rheumatoid arthritis patients whose MTX alone or MTX combined with biologics are non responsive. - Examination of structural remission and reduction of drug free of filgotinib in rheumatoid arthritis patients whose MTX alone or MTX combined with biologics are non responsive.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000043547

Enrollment

100

Registered

2021-03-08

Start date

2021-03-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis

Interventions

60 weeks Oral administration of 200mg filgotinib daily

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients who agree with participation of this study 2.Patients who are more than 20-years-old 3.Patients with filg0tinib administerable

Exclusion criteria

Exclusion criteria: 1.Patients with administration contraindication of JAK inhibitor 2.Patients with sensitivity for filgotinib 3.Patients prior to serious infection 4.Patients with active tuberculosis 5.Patients with end-stage renal failure 6.Patients with severe liver function 7.Patients with less than 1000/mm3 of neutrofils 8.Patients with less than 500/mm3 of lymphocytes 9.Patients with less than 8g/dL of hemoglobin 10.Patients with possibilities of pregnancy or feeding

Design outcomes

Primary

Measure	Time frame
1.Less than 0.5 of mTSS at 24 weeks after the start of this study 2.Less than 0.5 of mTSS at 60 weeks after the start of this study 3.Less than 2.6 of DAS28CRP at 24 weeks after the start of this study 4.Less than 2.6 of DAS28CRP at 60 weeks after the start of this study	—

Countries

Japan

Contacts

Public ContactYukio Nakamura

Shinshu University School of Medicine Department of Orthopaedic Surgery

yxn14@aol.jp0263372659

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026