food allergy
Conditions
Interventions
In intervention group A, pregnant women consume synbiotics (Lactobacillus rhamnosus GG, Bifidobacterium bifidum, and 1-kestose) daily from 34-35 weeks gestation until postpartum day 5, and newborns fr
Sponsors
National Hospital Organization Sagamihara National Hospital
Technical Research Laboratory Takanashi MilkProducts Co. Ltd. Japan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Pregnant women at 34 to 35 weeks gestation 2. Either the pregnant woman or her partner has one or more of the following allergic diseases: atopic dermatitis, bronchial asthma, food allergy, allergic rhinitis, allergic conjunctivitis 3. A child born on day 0 to a pregnant woman who meets the above criteria 1 and 2.
Exclusion criteria
Exclusion criteria: 1.The pregnant woman who has an obvious underlying medical condition 2.Twins 3.Premature birth or low birth weight infant 4.Severe neonatal asphyxia (Apgar score <4) 5.Children deemed by their doctor to be unsuitable for participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences and changes in the type and diversity of intestinal microflora in children at 4 months of age | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)Presence of immediate food allergy at 1 year of age (2)Changes in short-chain fatty acids in the blood (3)Differences and changes in the types and diversity of breast milk and skin flora (4)Sensitization to food allergen at 1 year of age (5)Presence and severity of eczema at 1 year of age (6)Stratify results affected by mode of delivery, method of child nutrition, and child skin condition | — |
Countries
Japan
Contacts
Public ContactYoko Miura
National Hospital Organization Sagamihara National Hospital Department of pediatrics
Outcome results
None listed