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Identification of predictive factors interacting with heart rate reduction therapy for potential clinical benefit in chronic heart failure: a systematic literature review and meta-analysis

Identification of predictive factors interacting with heart rate reduction therapy for potential clinical benefit in chronic heart failure: a systematic literature review and meta-analysis - Factors that interact with heart rate reduction in chronic heart failure

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000043495
Enrollment
Unknown
Registered
2021-03-02
Start date
2021-03-02
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic heart failure

Interventions

None listed

Sponsors

Ono Pharmaceutical Co., Ltd.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Study-level inclusion criteria: studies that were randomized and placebo-controlled clinical trials; studies published in English; studies with full text available; studies investigating the effect of HR reducing therapies on change in HR and/or other clinical outcomes; and studies published between database inception and December 2020. Patient-level inclusion criteria: patient population of adults aged >=18 years; and patient population with symptomatic chronic HF.

Exclusion criteria

Exclusion criteria: Case-control studies; observational studies; studies involving adults <18 years; studies not investigating HR-reducing therapy; studies with no quantitative data or measurable outcomes; studies with incomplete or qualitative data alone; and reviews and collections of conference abstracts

Design outcomes

Primary

MeasureTime frame
Primary: To measure the relative contributions of predictive factors on the effect of HR reduction on clinical outcomes in the context of HFrEF.—

Secondary

MeasureTime frame
Secondary: To show the strength of the interactions between HR reduction and predictive factors and their effect on clinical outcomes. Secondary: To measure the relative contributions of predictive factors on the effect of treatment on clinical outcomes in subgroups that have had their HR reduced by >=10 bpm or <10 bpm.—

Countries

Japan

Contacts

Public ContactMasanori Nishikori

Ono Pharmaceutical Co., Ltd. Medical Affairs

nishikohri@ono.co.jp06-6263-2992

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026