Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: a retrospective cohort study

Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: a retrospective cohort study - Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: a retrospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000043475

Enrollment

120

Registered

2021-03-01

Start date

2020-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

critical ill patients

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having started mechanical ventilation within 24 hours of ICU admission Requiring mechanical ventilation using an oral endotracheal tube for at least 48 hours

Exclusion criteria

Exclusion criteria: central nervous system disease (stroke, epilepsy, meningitis, encephalitis, etc.), cardiopulmonary arrest, traumatic brain injury, overdose, gastrointestinal tract impracticability (administration of continuous neuromuscular blockade, abdominal surgery, ileus, gastrointestinal bleeding, etc.), previous psychiatric or cognitive pathology, Child C hepatopathy, pregnancy, previous tracheostomy, ICU readmission, lacking body weight records, death in ICU, and not receiving propofol.

Design outcomes

Primary

Measure	Time frame
The average daily propofol dose per body weight administered as a continuous sedative during mechanical ventilation through an oral endotracheal tube.	—

Countries

Japan

Contacts

Public ContactTakefumi Tsunemitsu

Hyogo Prefectural Amagasaki General Medical Center Department of Emergency and Critical Care Medicine

tsunemitsu0730@yahoo.co.jp06-6480-7000

Outcome results