Elucidation of the pathophysiology of neurodevelopmental disorders by imaging analysis

Evaluation of neural circuits and chemical substances in the brain in neurodevelopmental disorders using MRI - Evaluation of neural circuits and chemical substances in the brain in neurodevelopmental disorders using MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000043450

Enrollment

Registered

2021-03-01

Start date

2022-08-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurodevelopmental disorders

Interventions

Sedatives should be given for MRI examination (intravenous administration for the patient group

oral or suppository for healthy sibs)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient group Patients whose causative gene abnormalities have already been identified by genetic analysis for the diagnosis of neurodevelopmental disorders. Healthy siblings Those who have not been diagnosed with neurodevelopmental disorders

Exclusion criteria

Exclusion criteria: 1. Persons with diseases for which safety cannot be guaranteed by participating in the study 2. Persons with physical conditions for which safety cannot be guaranteed by participating in the study

Design outcomes

Primary

Measure	Time frame
Brain structure data by MRI Neural circuit data by diffusion tensor imaging Measurement of chemical substances in the brain by MR spectroscopy	—

Secondary

Measure	Time frame
The medical information on height, weight, age, gender, complications, developmental index, and past MRI findings	—

Countries

Japan

Contacts

Public ContactHirotomo Saitsu

Hamamatsu University School of Medicine Department of Biochemistry

hsaitsu@hama-med.ac.jp053-435-2327

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026