The patients who receive general anesthesia
Conditions
Interventions
Surgical patients were randomized to remimazolam started at 12 mg/kg/h by continuous intravenous (IV) infusion until the loss of consciousness (LoC), followed by 1 mg/kg/h to be adjusted as appropriat
Sponsors
Sapporo Medical University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Relevant inclusion criteria included over 18 years old, a bodyweight of 100 kg or less, scheduled for elective surgery requiring tracheal intubation and an American Society of Anesthesiologists physical status of 1 or 2
Exclusion criteria
Exclusion criteria: Key exclusion criteria included emergency surgeries or patients with consciousness disturbance, drug dependence, alcohol dependence, uncontrolled hypertension, acute angle-closure glaucoma, myasthenia gravis, renal failure, massive hemorrhage, shock and pregnant and nursing women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in heart rate variability before and after anesthetic induction with propofol or remimazolam | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in blood pressure and heart rate before and after anesthetic induction with propofol for remimazolam | — |
Countries
Japan
Contacts
Public ContactNaoyuki Hirata
Sapporo Medical University School of Medicine Department of Anesthesiology
Outcome results
None listed