Breast cancer
Conditions
Interventions
About 1-1.5 hr after [18F]FES injection (approximately 111-222 MBq), PET/CT, dedicated breast PET, and/or PET/MR scanning will be performed. A small amount of blood will be collected at the time of [1
Sponsors
Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 20 years of age at the time of consent 2. Patients who have been diagnosed with breast cancer or have a strong clinical or imaging suspicion of breast cancer. 3. Patients who have completed the written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients who received selective estrogen receptor modulators (SERMs) or selective estrogen down regulators (SERDs) within 5 weeks prior to [18F] FES-PET 2. Patient who had adverse reactions to [18F]FES in the past 3. Women who are or may be pregnant 4. Patients in extremely poor general condition 5. Patients with significant communication difficulties 6. Patients judged not to be appropriate for attending this study by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qualitative and quantitative parameters of [18F]FES-PET will be correlated with patient prognosis, and with the therapeutic effects measured by image monitoring or pathological evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison among PET systems and optimization of examination methods and image reconstruction parameters - Verification of pathological and clinical features related to [18F]FES accumulation - Comparison and validation with existing diagnostic examinations for breast cancer - Construction of a diagnostic algorithm using a multi-marker approach combining multiple tests - Utility as an imaging guide for surgery and biopsy | — |
Countries
Japan
Contacts
Public ContactKanae Miyake
Kyoto University Graduate School of Medicine Department of Advanced Medical Imaging Research
Outcome results
None listed