Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma

Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma - ALP, LDH, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000043289

Enrollment

Registered

2021-12-19

Start date

2017-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteosarcoma patient

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients who were diagnosed with osteosarcoma as regards clinicopathological conference (CPC); and who underwent 3 cycles of neoadjuvant chemotherapy. They had complete clinical evaluation [pain and musculoskeletal tumor society score (MSTS)], laboratory and radiologic examinations [magnetic resonance imaging (MRI) before and after neoadjuvant chemotherapy)];and histopathological results before and after surgery (percentage of tumor necroses as regards Huvos grading. Neoadjuvant chemotherapy regimens were adjusted with our institution using cisplatin, adriamycin, and iphosphamide (CAI) for pediatric patients (< 18 years old) and cisplatin and adriamycin (CA) for adult patients.

Exclusion criteria

Exclusion criteria: Lost to follow-up

Design outcomes

Primary

Measure	Time frame
ALP, ESR, NLR, LDH, LMR, tumor size, and MSTS Score	—

Countries

Asia(except Japan)

Contacts

Public ContactAchmad Kamal

Dr. Cipto Mangunkusumo Jakarta Department of Orthopaedic and Traumatology

fauzikamal@yahoo.com+621511450189

Outcome results