Relationship between chewing and tear production in healthy young subjects

Study of chewing and tear production in healthy young subjects - Study of chewing and tear production in healthy subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000043106

Enrollment

Registered

2021-01-23

Start date

2021-01-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adult

Interventions

Gum chewing of two pieces during Schirmer I test with topical anesthesia (once, max 5 minutes). No gum chewing during Schirmer I test with topical anesthesia (once, max 5 minutes)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Twenty four eyes of 12 healthy subjects between 20 and 29 years old.

Exclusion criteria

Exclusion criteria: (1) Subjects who do not like the mint taste. (2) Subjects who inability to chew gum. (3) Subjects with sufficiently severe dry eye such that refraining from blinking for 5 seconds was impossible. (4) Subjects had side effects (hyperemia and corneal erosion) caused by oxybuprocaine hydrochloride.

Design outcomes

Primary

Measure	Time frame
Value of tear production before and after chewing gum	—

Countries

Japan

Contacts

Public ContactKen Asakawa

School of Allied Health Sciences, Kitasato University Department of Orthoptics and Visual Science

asaken@kitasato-u.ac.jp042-778-9667

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026