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Observational study on the changes in oral and intestinal microbiota before and after the use ofantimicrobials

Observational study on the changes in oral and intestinal microbiota before and after the use ofantimicrobials - Observational study on the changes in oral and intestinal microbiota before and after the use ofantimicrobials

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000043072
Enrollment
60
Registered
2021-01-22
Start date
2020-10-12
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectiouse diseases

Interventions

None listed

Sponsors

Disease Control and Prevention Center (DCC), National Center for Global Health and Medicine (NCGM)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients who are 20 years or over and a Japanese national 2) Patients who are prescribed carbapenems and cephamycin/oxacephem antibiotics in the department of infectious diseases, general internal medicine, emergency medicine, or critical care of the NCGM 3) Patients who will continuously take antibiotics for more than 3 days, including the first day of taking the antibiotics

Exclusion criteria

Exclusion criteria: 1) Patients who have used antibiotics during the past 2 months 2) Patients who need to take carbapenems and cephamycin/oxacephem antibiotics together with other antibiotics 3) Patients to whom rectal swab sample collection cannot be applied e.g., patients with a stoma 4) Patients who have had a colectomy 5) Patients with a history of any hypersensitivity to carbapenems and cephamycin/oxacephem antibiotics 6) Patients whom the investigator deemed to be inappropriate for participation in the study

Design outcomes

Primary

MeasureTime frame
The composition ratio of each type of microbes and that of functional genes of microbiomes

Countries

Japan

Contacts

Public ContactSho Saito

National Center for Global Health and Medicine (NCGM) Disease Control and Prevention Center (DCC)

ssaito@hosp.ncgm.go.jp03-3202-7181

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026