Effect of esaxerenone on oxidative stress and proteinuria in hypertensive patients with type 2 diabetes who have albuminuria

Effect of esaxerenone on oxidative stress and proteinuria in hypertensive patients with type 2 diabetes who have albuminuria - Effect of esaxerenone on oxidative stress and proteinuria in hypertensive patients with type 2 diabetes who have albuminuria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000043069

Enrollment

Registered

2022-01-01

Start date

2021-02-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes and hypertension

Interventions

Esaxerenone group Angiotensin receptor antagonist group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)hypertensive patients with type 2 diabetes who have albuminuria. 2)regular doses of angiotensin receptor blockers for at least 12 weeks 3)blood pressure in Examination room (systolic blood pressure more than 130 mmHg or diastolic blood pressure more than 80 mmHg) 4)HbA1c less than 8.5%

Exclusion criteria

Exclusion criteria: 1)the use of steroids or anti-inflammatory drugs 2)diabetic ketosis and coma within 3 months before the study 3)severe infection, severe trauma, pre-and post-operation 4)an estimated glomerular filtration rate are within 30mL/min/1.73m2 5)hyperkalemia or serum potassium levels above 5.0 mEq / L 6)malignancy 7)pregnancy 8)Patients who are judged as inappropriate for inclusion by phsicians

Design outcomes

Primary

Measure	Time frame
Oxidative stress and urinary albumin	—

Countries

Japan

Contacts

Public ContactMakoto Ohara

Showa University School of Medicine Division of Diabetes and Endocrinology, Department of Internal Medicine

s6018@nms.ac.jp0337848000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026