Anal canal squamous cell carcinoma
Conditions
Interventions
We will evaluate the presence or absence of early cancer, and the degree of progression of precancerous lesions (AIN1 to 3) by HRA in MSMs with abnormal findings on anal cytology. Patients with precan
Sponsors
National Center for Global Health and Medicine, Japan Institute for Health Security
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Persons who have obtained written consent for participation in the research 2) MSM whose age at the time of obtaining consent is 20 years or older 3) Persons diagnosed with precancerous lesions as defined below by anal scraping cytology Definition of precancerous lesions: Low grade squamous intraepithelial lesion (LSIL), atypical squamous cells, cannot exclude HSIL (ASC-H), high grade squamous intraepithelial lesion (HSIL), or atypical squamous cells of undetermined significance (ASC-US) with positive high-risk anal HPV
Exclusion criteria
Exclusion criteria: 1) Those who are allergic to local anesthesia 2) Those who are judged by the principal researcher to be inappropriate for inclusion in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HRA histological diagnosis will show the degree of anal intra-epitherial neoplasia (AIN) (grade 1-3) and prevalence of anal canal cancer | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of change in the degree of anal intra-epitherial neoplasia (AIN) (1 to 3) after histological diagnosis by HRA | — |
Countries
Japan
Contacts
Public ContactNaokatsu Ando
National Center for Global Health and Medicine, Japan Institute for Health Security AIDS Clinical Center
Outcome results
None listed