Head and neck cancer
Conditions
Interventions
- Iodine solution (Intervention) - Gargle 30 ml for 30 seconds - 3 times a day after meal - From the first day of concurrent chemoradiation to the day of completion
- Normal saline solution (Contro
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients should be diagnosed with head and neck cancer without distant metastasis. 2) Patients should be between 18 -70 years old of age. 3) Patient should be receiving concurrent chemotherapy with a platinum-based agent. 4) Oral mucosa should be included in the radiation field. 5) The planned radiation dose to the primary tumor should exceed 50 Gy.
Exclusion criteria
Exclusion criteria: 1) Patients with an Eastern Cooperative Oncology Group Performance Score more than 2. 2) Patients with an allergy to iodine and/or seafood. 3) Patients who were unable to take part in the follow up schedule. 4) Patients who were pregnant or lactating. 5) Patients who had undergone prior radiation therapy. 6) Patients who were diagnosed with more than one primary cancer. 7) Patients who were diagnosed with hematologic malignancies. 8) Patients who were to undergo radiation therapy with altered fractionation. 9) Patients who were previously treated with hyperbaric oxygen therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral Mucositis Assessment Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| - Pain score - Impact on swallowing score - Incidence, severity, onset, & duration of oral mucositis - Analgesic drug use - Total treatment break - Secondary infection of oral mucosa. | — |
Countries
Asia(except Japan)
Contacts
Public ContactYOTDANAI NAMUANGCHAN
Khon Kaen University Division of Radiation Oncology, Department of Radiology, Faculty of Medicine
Outcome results
None listed