Colorectal serrated lesion
Conditions
Interventions
Observation of the entire proximal colon using chromoendoscopy (indigo carmine) during total colonoscopy.
Sponsors
National Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study participants will be average-risk individuals (age: 40-74 years) undergoing total colonoscopy (TCS) for colorectal cancer screening for the first time in their lives at the participating institutions, who will receive a full oral explanation of the study using written materials, and who will provide consent in writing. Both individuals undergoing their first TCS for screening purposes and those undergoing first TCS following a positive fecal occult blood test in colorectal cancer screening are included in this study.
Exclusion criteria
Exclusion criteria: 1) Presence of uncontrollable complications, including unstable angina, acute myocardial infarction, heart failure, chronic respiratory disease, bleeding tendency, that make it difficult to safely perform TCS. 2) Clinical symptoms that indicate colorectal cancer, such as hematochezia or abdominal pain. 3) History of treatment for colorectal cancer or colorectal tumor. 4) History of colorectal surgery in which colorectum was resected. (Surgery not involving resection of colorectum such as appendectomy for appendicitis is not included in exclusion criteria) 5) Being from a family with hereditary colorectal cancer. 6) Difficult to survey baseline factors using a questionnaire. 7) Does not provide written consent. 8) Otherwise determined to be unfit by an investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colorectal SSL (sessile serrated lesion) | — |
Secondary
| Measure | Time frame |
|---|---|
| Non-SSL colorectal lesions (including non-SSL colorectal serrated lesions, colorectal cancer, advanced colorectal neoplasia, and colorectal adenoma), Serrated polyposis syndrome | — |
Countries
Japan,Asia(except Japan)
Contacts
Public ContactMasau Sekiguchi
National Cancer Center Hospital Cancer Screening Center/ Endoscopy Division
Outcome results
None listed