A Multicenter Prospective Observational Study of Sodium-glucose Cotransporter-2 Inhibitors-Associated Postoperative Ketoacidosis

A Multicenter Prospective Observational Study of Sodium-glucose Cotransporter-2 Inhibitors-Associated Postoperative Ketoacidosis - The SAPKA Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000042795

Enrollment

750

Registered

2021-01-01

Start date

2021-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Written informed consent 2. Aged older than 19 yr 3. Diagnosed with diabetes 4. Undergoing surgery under general anesthesia 5. Taking one of the SGLT2 inhibitors listed below a. Apleway b. Canaglu c. Canalia d. Deberza e. Forxiga f. Jardiance g. Lusefi h. Suglat i. Sujanu j. Tradiance

Exclusion criteria

Exclusion criteria: 1. Diagnosed with ketoacidosis at the screening or anesthesia induction 2. Secessed SGLT2 inhibitors more than one week prior to surgery 3. Surgery is performed without general anesthesia

Design outcomes

Primary

Measure	Time frame
Incidence of ketoacidosis within 3 days after surgery	—

Secondary

Measure	Time frame
Risk factors for developing ketoacidosis	—

Countries

Japan

Contacts

Public ContactHiroyuki Seki

Kyorin University School of Medicine Department of Anesthesiology

hseki@ks.kyorin-u.ac.jp0422-43-1504

Outcome results